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Search Results for " nedd8-activating enzyme "

10

Compounds

Cat No. Product Name Synonyms Targets
T5374 NAcM-OPT E1/E2/E3 Enzyme , NEDD8
NAcM-OPT is a specific, reversible inhibitor targeting N-Acetyl-UBE2M interaction with DCN1 (IC50: 79 nM).
T8816 NAE-IN-M22 NEDD8 inhibitor M22 Apoptosis , E1/E2/E3 Enzyme
NAE-IN-M22 (NEDD8 inhibitor M22) is a selective, potent and reversible inhibitor of NEDD8 activating enzyme (NAE). NAE-IN-M22 inhibits multiple cancer cell lines and induces apoptosis in A549 cells. NAE-IN-M22 also can i...
T6332 Pevonedistat MLN4924 E1/E2/E3 Enzyme , NEDD8
Pevonedistat (MLN4924) is a potent and selective NEDD8 activating enzyme (NAE) inhibitor (IC50=4.7 nM). Pevonedistat can be used for the treatment of myelodysplastic syndromes (MDS) and also has antitumor activity.
T13090 TAS4464 hydrochloride E1/E2/E3 Enzyme , NEDD8
TAS4464 hydrochloride is a highly potent and selective NEDD8 activating enzyme (NAE) inhibitor(IC50 of 0.955 nM).
T13412 ZM223 ZM-223 E1/E2/E3 Enzyme
ZM223 is an inhibitor of NEDD8 activating enzyme (NAE).
T16102 ML-792 E1/E2/E3 Enzyme
ML-792 is a specific small ubiquitin-like modifier (SUMO)-activating enzyme (SAE) inhibitor. Compared with NAE/NEDD8 and UAE/ubiquitin (IC50s of 32 μM and >100 μM, respectively), ML-792 is an effective and selective inhi...
T16117 Pevonedistat hydrochloride MLN4924 hydrochloride Others
Pevonedistat hydrochloride is an effective and selective inhibitor of NEDD8-activating enzyme (IC50: 4.7 nM).
T13412L ZM223 hydrochloride (2031177-48-5 free base) ZM223 hydrochloride Serine Protease
ZM223 hydrochloride is an orally active, potent non-covalent inhibitor of NEDD8 activating enzyme (NAE), and with excellent anticancer activity.
T13090L TAS4464 E1/E2/E3 Enzyme
TAS4464 is a highly potent and selective inhibitor of the NEDD8 activating enzyme (IC50: 0.955 nM).
TN1570 Deoxyvasicinone Others
Deoxyvasicinone derivatives can be considered as promising lead molecules for the development of more potent inhibitors of NEDD8-activating enzyme.
TargetMol