10
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T5374 | NAcM-OPT | E1/E2/E3 Enzyme , NEDD8 | |
NAcM-OPT is a specific, reversible inhibitor targeting N-Acetyl-UBE2M interaction with DCN1 (IC50: 79 nM). | |||
T8816 | NAE-IN-M22 | NEDD8 inhibitor M22 | Apoptosis , E1/E2/E3 Enzyme |
NAE-IN-M22 (NEDD8 inhibitor M22) is a selective, potent and reversible inhibitor of NEDD8 activating enzyme (NAE). NAE-IN-M22 inhibits multiple cancer cell lines and induces apoptosis in A549 cells. NAE-IN-M22 also can i... | |||
T6332 | Pevonedistat | MLN4924 | E1/E2/E3 Enzyme , NEDD8 |
Pevonedistat (MLN4924) is a potent and selective NEDD8 activating enzyme (NAE) inhibitor (IC50=4.7 nM). Pevonedistat can be used for the treatment of myelodysplastic syndromes (MDS) and also has antitumor activity. | |||
T13090 | TAS4464 hydrochloride | E1/E2/E3 Enzyme , NEDD8 | |
TAS4464 hydrochloride is a highly potent and selective NEDD8 activating enzyme (NAE) inhibitor(IC50 of 0.955 nM). | |||
T13412 | ZM223 | ZM-223 | E1/E2/E3 Enzyme |
ZM223 is an inhibitor of NEDD8 activating enzyme (NAE). | |||
T16102 | ML-792 | E1/E2/E3 Enzyme | |
ML-792 is a specific small ubiquitin-like modifier (SUMO)-activating enzyme (SAE) inhibitor. Compared with NAE/NEDD8 and UAE/ubiquitin (IC50s of 32 μM and >100 μM, respectively), ML-792 is an effective and selective inhi... | |||
T16117 | Pevonedistat hydrochloride | MLN4924 hydrochloride | Others |
Pevonedistat hydrochloride is an effective and selective inhibitor of NEDD8-activating enzyme (IC50: 4.7 nM). | |||
T13412L | ZM223 hydrochloride (2031177-48-5 free base) | ZM223 hydrochloride | Serine Protease |
ZM223 hydrochloride is an orally active, potent non-covalent inhibitor of NEDD8 activating enzyme (NAE), and with excellent anticancer activity. | |||
T13090L | TAS4464 | E1/E2/E3 Enzyme | |
TAS4464 is a highly potent and selective inhibitor of the NEDD8 activating enzyme (IC50: 0.955 nM). | |||
TN1570 | Deoxyvasicinone | Others | |
Deoxyvasicinone derivatives can be considered as promising lead molecules for the development of more potent inhibitors of NEDD8-activating enzyme. |